15-Lipoxygenase Inhibitor 1 是 15-lipoxygenase 的选择性抑制剂，IC50 为 18 μM. 15-脂氧合酶抑制剂 1 对大豆 15-脂氧合酶 (SLO) 和人 15-脂氧合酶-1 (15-LOX-1) 的 IC50 分别为 19.5 μM 和 19.1 μM。 15-Lipoxygenase Inhibitor 1 具有研究前列腺癌的潜力。
| Cas No. | 928853-86-5 |
| Canonical SMILES | CC1=C(NC(C=CC=C2)=C2S3)C3=NC(N4CCN(C)CC4)=N1 |
| 分子式 | C16H19N5S |
| 分子量 | 313.4 |
| 溶解度 | Chloroform: >5mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Lipoxygenases (LOs) are non-heme iron-containing dioxygenases that catalyze the oxidation of polyunsaturated fatty acids to generate unsaturated fatty acid hydroperoxides. The immediate products of 15-LO fatty acid oxidation act as mediators in inflammation, thrombosis, and cancer. 15-Lipoxygenases (15-LO) inhibitor 1 is a heterocyclic pyrimidobenzothiazine compound that inhibits 15-LO with an IC50 value of 18 µM. The inhibitor appears to act as an antioxidant, interfering with the redox cycle of 15-LO. |
