Valilactone 是一种强效的酯酶抑制剂，由放线菌产生。
| Cas No. | 113276-96-3 |
| 别名 | 缬基内酯,(-)-Valilactone |
| Canonical SMILES | CCCCC[C@H](OC([C@@H](NC([H])=O)C(C)C)=O)C[C@H]1[C@H](CCCCCC)C(O1)=O |
| 分子式 | C22H39NO5 |
| 分子量 | 397.6 |
| 溶解度 | DMF: 25 mg/ml,DMSO: 25 mg/ml,DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml,Ethanol: 10 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Valilactone is an esterase inhibitor produced by a cultured strain of soil actinomycetes. It is reported to inhibit hog liver esterase and hog pancreas lipase with IC50 values of 29 and 0.14 ng/ml, respectively. Valilactone can also inhibit fatty acid synthase with an IC50 value of 0.30 µM and demonstrates selective toxicity towards MDA-MB-231 breast cancer cells with an IC50 value of 10.5 µM. |
