Buthionine sulfoximine

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CAS NO:

83730-53-4

包装与价格：

包装	价格(元)
250mg	询价
500mg	询价
1g	询价

化学性质

Physical Appearance	A crystalline solid
Storage	Store at -20°C
M.Wt	222.31
Cas No.	83730-53-4
Formula	C₈H₁₈N₂O₃S
Solubility	≤50mg/ml in PBS, pH 7.2
Chemical Name	(2S)-2-amino-4-(butylsulfonimidoyl)butanoic acid
Canonical SMILES	O=S(CCCC)(CC[C@@H](C(O)=O)N)=N
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

L-Buthionine-(S,R)-sulfoximine is a cell-permeable, irreversible inhibitor of g-glutamylcysteine synthetase[1].

In ZAZ and M14 melanoma cell line, L-Buthionine-(S,R)-sulfoximine (50 μM) treatment for 48 hr results in a 95% decrease in GSH levels, and a 60% decrease in GST enzyme activity. GST-mu protein and mRNA levels are significantly reduced in both cell lines[1].

L-Buthionine-(S,R)-sulfoximine (BSO) treatment significantly increases the frequency of DNA deletions and reduces concentrations of GSH and cysteine. BSO (20 mM) treatment results in a 40% increase in DNA deletion frequency, a 70% decrease in GSH, and a 55% decrease in cysteine levels[2].

References：

[1]. Fruehauf J P, et al. Selective and synergistic activity of L-S,R-buthionine sulfoximine on malignant melanoma is accompanied by decreased expression of glutathione-S-transferase. Pigment Cell Res, 1997, 10(4): 236-49.

[2]. Reliene R, et al. Glutathione depletion by buthionine sulfoximine induces DNA deletions in mice. Carcinogenesis, 2006, 27(2): 240-4.