Necrotatin-7 (Nec-7) 是一种有效的坏死性凋亡抑制剂，EC50 为 10.6 μM。 Necrotatin-7 不抑制重组 RIP1 激酶。
| Cas No. | 351062-08-3 |
| 别名 | 5-[[3-(4-氟苯基)-1H-吡唑-4-基]亚甲基]-2-亚氨基-3-(2-噻唑基)-4-噻唑烷酮,Nec-7 |
| Canonical SMILES | O=C(N(C1=NC=CS1)C(S/2)=N)C2=C\C3=CN([H])N=C3C4=CC=C(F)C=C4 |
| 分子式 | C16H10FN5OS2 |
| 分子量 | 371.4 |
| 溶解度 | DMSO: Soluble,Ethanol: Soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Serine/threonine kinase activity of the death domain receptor-associated molecule RIP1 is thought to be essential for Fas ligand-induced and tumor necrosis factor-α (TNF-α) induced necrosis. Necrostatin-7 (Nec-7) is a necroptosis inhibitor that is structurally and biologically distinct from necrostatin-1, -3, -4, and -5 as it does not inhibit RIP1 kinase. Nec-7 may target an additional regulatory molecule in this pathway as it inhibits TNF-α-induced necroptosis in a FADD-deficient variant of human Jurkat T cells with an EC50 value of 10.6 μM. |
