N-Acetyl-4-benzoquinone imine 是对乙酰氨基酚的有毒代谢物。
| Cas No. | 50700-49-7 |
| 别名 | N-乙酰基-4-苯醌亚胺 |
| Canonical SMILES | O=C(C=C/1)C=CC1=N\C(C)=O |
| 分子式 | C8H7NO2 |
| 分子量 | 149.2 |
| 溶解度 | Chloroform: 1 mg/ml*,Chloroform/Ethyl Acetate (1:1): 1 mg/ml,Ether: 1 mg/ml,Ethyl Acetate: 1 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | N-Acetyl-4-benzoquinone imine (NAPQI) is a cytochrome P450 3A4 and 2E1 metabolite of acetaminophen that can be toxic to the liver when acetaminophen is consumed in large doses. At therapeutic doses of acetaminophen, NAPQI is inactivated by conjugation with glutathione. However, following toxic doses of acetaminophen, available liver reserves of glutathione are quickly depleted due to clearance of excess NAPQI, which enables hepatic proteins to become covalently modified by reactive metabolites and eventually results in hepatocyte necrosis. |
