ML-299 是一种选择性变构调节剂和磷脂酶 D1 和 D2 的双重抑制剂（IC50 值分别为 6 和 12 nM）。 ML-299 减少 U87-MG 胶质母细胞瘤细胞的侵袭性迁移。
| Cas No. | 1426916-00-8 |
| Canonical SMILES | BrC1=CC=C(C(N[C@@H](C)CN2CCC3(C(NCN3C4=CC(F)=CC=C4)=O)CC2)=O)C=C1 |
| 分子式 | C23H26BrFN4O2 |
| 分子量 | 489.4 |
| 溶解度 | DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:20): 0.5 mg/ml,DMSO: 25 mg/ml,Ethanol: 1 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | ML-299 is a dual inhibitor of the two mammalian forms of phospholipase D (PLD), PLD1 and PLD2 (IC50s = 6 and 20 nM, respectively). It dose-dependently decreases the invasive migration of U98-MG glioblastoma cells into matrigel. ML-299 penetrates the central nervous system and is functional in vivo when given intraperitoneally. As PLD1 and PLD2 have roles in cancer and viral infection, ML-299 has potential applications in oncology and virology. |
