L-Leucyl-L-Leucine methyl ester(hydrochloride)

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CAS NO:

6491-83-4

包装与价格：

包装	价格(元)
100mg	询价
250mg	询价
1g	询价

化学性质

Physical Appearance	A crystalline solid
Storage	Store at -20°C
M.Wt	294.82
Cas No.	6491-83-4
Formula	C₁₃H₂₇ClN₂O₃
Solubility	≥47.5 mg/mL in EtOH; ≥48.8 mg/mL in DMSO; ≥92.2 mg/mL in H2O
Chemical Name	(S)-methyl 2-((S)-2-amino-4-methylpentanamido)-4-methylpentanoate hydrochloride
Canonical SMILES	COC([C@H](CC(C)C)NC([C@H](CC(C)C)N)=O)=O.Cl
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

L-Leucyl-L-Leucine methyl ester (LLME) is a lysosomal condensation product that has been reported to be cytotoxic towards natural killer cells and CD4⁺ and CD8⁺ T lymphocytes without affecting helper T cells and B cells[1,2]. It has also been shown to induce death of monocytes, polymorphonuclear leukocytes, and myeloid tumor cells[2]. Upon entry into cells via receptor-mediated endocytosis, LLME undergoes a condensation process catalyzed by dipeptidyl peptidase I (DPPI) in lysosomes. This condensation leads to lysosomal rupture and DNA fragmentation in DPPI-expressing immune cells such as cytotoxic T cells and natural killer cells[2].

References:

[1]. Ohlin M, Danielsson L, Carlsson R, et al. The effect of leucyl-leucine methyl ester on proliferation and Ig secretion of EBV-transformed human B lymphocytes. Immunology, 1989, 66(4): 485-490.

[2]. Thiele D L, Lipsky P E. Mechanism of L-leucyl-L-leucine methyl ester-mediated killing of cytotoxic lymphocytes: Dependence on a lysosomal thiol protease, dipeptidyl peptidase I, that is enriched in these cells. Proceedings of the National Academy of Sciences of the United States of America, 1990, 87(1): 83-87.