(S)-Ketoprofen

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(S)-Ketoprofen

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

22161-81-5

包装与价格：

包装	价格(元)
10mM (in 1mL DMSO)	询价
500mg	询价
1g	询价
5g	询价

化学性质

Storage	Store at -20°C
M.Wt	254.3
Cas No.	22161-81-5
Formula	C₁₆H₁₄O₃
Synonyms	(S)-2-(3-benzoylphenyl)Propionic Acid,Dexketoprofen
Solubility	insoluble in H2O; ≥10.6 mg/mL in DMSO; ≥20.55 mg/mL in EtOH
Chemical Name	(S)-3-benzoyl-α-methyl-benzeneacetic acid
Canonical SMILES	O=C(C1=CC=CC([C@H](C)C(O)=O)=C1)C2=CC=CC=C2
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

(S)-Ketoprofen, a dual COX1/2 inhibitor, can be used as a nonsteroidal anti-inflammatory drug to treat arthritis-related inflammatory pains. Ketoprofen is photolabile and undergoes degradation when irradiated by sunlight to induce various skin diseases [1].

In vitro: The combination of UVB irradiation with ketoprofen dose-dependently induced the cytotoxicity and suppressed DNA synthesis in HaCaT cells. UVB-irradiated KP inhibited the cell growth and induced G2/M cell cycle arrest by regulating the levels of cdc2, cyclin B1, Chk1, Tyr15-phosphorylated cdc2 and p21. The DAPI staining results has revealed that KP accentuated the apoptotic response to UVB radiation in HaCaT cells [1].

In vivo: In a placebo-controlled, double-blind study in the rhesus monkeys Macaca mulatta with periodontal disease, administeration of KP at 1% level in suitable topical vehicles to the gingiva once daily at a standard dose of 1.8 ml per monkey for 6 months effectively inhibited GCF-LTB4 and GCF-PGE2 and positively altered alveolar bone activity [2]. Ketoprofen at a dose of 3.63 mg/kg bwt (phenylbutazone equimolar dose) showed significant analgesic effects and reduced hoof pain and lameness to a greater extent [3]. Treatment with Ketoprofen (40 and 80 mg/kg diet) greatly reduced the incidence of transitional cell carcinoma of the urinary bladder by >70% from that seen in dietary mice [4].

References:
[1]. Liu S, Mizu H, Yamauchi H. Molecular response to phototoxic stress of UVB-irradiated ketoprofen through arresting cell cycle in G2/M phase and inducing apoptosis[J]. Biochemical and biophysical research communications, 2007, 364(3): 650-655.
[2]. Li K L, Vogel R, Jeffcoat M K, et al. The effect of ketoprofen creams on periodontal disease in rhesus monkeys[J]. Journal of periodontal research, 1996, 31(8): 525-532.
[3]. Owens J G, Kamerling S G, Stanton S R, et al. Effects of ketoprofen and phenylbutazone on chronic hoof pain and lameness in the horse[J]. Equine Veterinary Journal, 1995, 27(4): 296-300.
[4]. Hawk E T, Kelloff G J, McCormick D L. Differential activity of aspirin, ketoprofen and sulindac as cancer chemopreventive agents in the mouse urinary bladder[J]. Carcinogenesis, 1996, 17(5): 1435-1438.