Phenyl sulfate

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Phenyl sulfate

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CAS NO:

937-34-8

包装与价格：

包装	价格(元)
5mg	询价
25mg	询价

化学性质

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	174.17
Cas No.	937-34-8
Formula	C₆H₆O₄S
Solubility	insoluble in EtOH; ≥17.4 mg/mL in DMSO; ≥37.75 mg/mL in H2O
Chemical Name	phenyl hydrogen sulfate
Canonical SMILES	OS(OC1=CC=CC=C1)(=O)=O
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Phenyl sulfate is a protein-bound uremic solute [1].

Phenyl sulfate is one of the protein-bound uremic solutes which have been reported to induce reactive oxygen species production and decrease glutathione levels, rendering the cells vulnerable to oxidative stress. Phenyl sulfate accumulates in chronic kidney disease patients, and was proposed as a novel biomarker for the effect of AST-120, an orally administered spherical carbon adsorbent that can adsorb various small molecule uremic toxins [1].

In porcine renal tubular cells, phenyl sulfate (0, 0.2, 0.5, 2, 5, 10 mmol/L) decreased glutathione levels in a dose-dependent manner. In 0.5, 2, 5, or 10 mmol/L phenyl sulfate-treated cells, 20 μmol/L of hydrogen peroxide decreased cellular viability by 76%, 81%, 89%, and 94%, respectively, whilst in control cells, the same concentration of hydrogen peroxide only decreased cellular viability by 62%. These differences between control cells and phenyl sulfate-treated cells were statistically significant [1].

In KKAy mice fed on a high-fat diet (HFD), oral administration of 50 mg/kg phenyl sulfate for 6 weeks increased albuminuria. Electron micrographs revealed podocyte effacement, as well as glomerular basement membrane thickening and damage in the PS-treated HFD-KKAy kidney [2].

References:

[1]. Edamatsu T, Fujieda A, Itoh Y. Phenyl sulfate, indoxyl sulfate and p-cresyl sulfate decrease glutathione level to render cells vulnerable to oxidative stress in renal tubular cells. PLoS One, 2018, 13(2): e0193342.

[2]. Kikuchi K, Saigusa D, Kanemitsu Y, et al. Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease. Nature Communications, 2019, 10(1): 1835.