描述
| Gene ID: | 841 | Accession #: | Q14790 |
| Alternate Names: | Active Human Caspase-8, Active Caspase-8, Caspase-8 Enzyme, Recombinant caspase-8, human caspase-8, human caspases, active caspases. |
| Source: | Escherichia Coli. | M.Wt: | N/A |
| Appearance: | Lyophilized powder | Storage: | Store at -70℃ |
| Formulation: | Lyophilized powder |
| Solubility: | Reconstitute to 1 unit per μl in PBS containing 15% glycerol. |
| Shipping Condition: | Gel pack. | Handling: | Centrifuge the vial prior to opening. |
| Usage: | For Research Use Only! Not to be used in humans. |
资料参考
Caspase-8 (also called FLICE, MASH, Mch5) belongs to the caspase-family of cysteine proteases. Caspase-8 like other caspases also exists in cells as an inactive proenzyme. Sequential activation of caspases plays a key role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymescomposed of a prodomain, a large and a small protease subunit. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. Active caspase-8 has been demonstrated to activate caspase-3 leading to degradation of a various of cellular target proteins during apoptosis. The recombinant active human caspase-8 was expressed in E. coli.生物活性
| Specific activity | > 5000 units/mg. |
