QStatin 是一种有效的选择性弧菌群体感应 (QS) 抑制剂，在不同的弧菌物种中显示出不同的 QS 抑制剂活性。QStatin 减弱了各种弧菌物种中代表性的 QS 调节表型，与 SmcR 中的假定配体结合口袋紧密结合，并改变蛋白质的灵活性，从而改变其转录调节活性。QStatin 可能是一种可用于水产养殖的可持续抗病毒剂。
| Cas No. | 902688-24-8 |
| Canonical SMILES | O=S(N1N=CC=C1)(C2=CC=C(Br)S2)=O |
| 分子式 | C7H5BrN2O2S2 |
| 分子量 | 293.16 |
| 溶解度 | DMSO: 83.33 mg/mL (284.25 mM) |
| 储存条件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | QStatin is a novel, potent, and selective Vibrio quorum sensing (QS) inhibitor, shows pan-QS inhibitor activity in diverse Vibrio species. QStatin attenuates representative QS-regulated phenotypes in various Vibrio speciesbinds tightly to a putative ligand-binding pocket in SmcR and changes the flexibility of the protein, thereby altering its transcription regulatory activity. QStatin may be a sustainable antivibriosis agent useful in aquacultures[1]. [1]. Kim BS, et al. QStatin, a Selective Inhibitor of Quorum Sensing in Vibrio Species. MBio. 2018 Jan 30;9(1). pii: e02262-17. |
