Kisspeptin 234

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Kisspeptin 234

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	1145998-81-7
包装:	1mg
市场价:	3212元

化学性质

Physical Appearance	White lyophilised solid
Storage	Store at -20°C
M.Wt	1295.42
Cas No.	1145998-81-7
Formula	C₆₃H₇₈N₁₈O₁₃
Solubility	insoluble in DMSO; insoluble in EtOH; ≥4.44 mg/mL in H2O with ultrasonic
Chemical Name	(S,Z)-N'1-((6S,7Z,9R,10Z,13Z,15S,16Z,19Z,21S,22Z,24S)-9-((1H-indol-3-yl)methyl)-1-amino-15-benzyl-8,11,14,17,20,23-hexahydroxy-6-((Z)-hydroxy(((S)-1-hydroxy-1-imino-3-phenylpropan-2-yl)imino)methyl)-21-(2-hydroxy-2-iminoethyl)-1-imino-25-(1H-indol-3-yl)-2
Canonical SMILES	C[C@](/N=C(O)/C)([H])/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/C/C(O)=N/[C@@](/C(O)=N/C/C(O)=N/[C@](/C(O)=N/[C@@](/C(O)=N/[C@@](C(O)=N)([H])CC1=CC=CC=C1)([H])CCCNC(N)=N)([H])CC2=CNC3=CC=CC=C23)([H])CC4=CC=CC=C4)([H])CC(O)=N)([H])CC5=CNC6=CC=CC=C56
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Kisspeptin 234 is a kisspeptin receptor antagonist, with the ability to antagonize kisspeptin-10-induced activation of gpr-54. Kisspeptin binds to its cognate receptor (i.e. gpr-54) on neurons that produce gonadotropin-releasing hormone (GnRH), and stimulates their activity, which in turn sends an obligatory signal for GnRH secretion, thereby gating down-stream events supporting reproduction. The development of kisspeptin receptor antagonists may provide a valuable tool for exploring the physiological and pathophysiological roles of kisspeptin in the regulation of reproduction, and could serve as a potential therapeutic agent for treating hormone-dependent disorders of reproduction, such as precocious puberty, endometriosis, as well as metastatic prostate cancer.

Reference:

1. Roseweir AK, Kauffman AS, Smith JT, et al. Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation. Journal of Neuroscience, 2009, 29(12): 3920-3929.

试验操作

Cell experiment:[1]
Cell lines	GnRH neurons
Reaction Conditions	100 pM ~ 10 μM kisspeptin 234
Applications	Kisspeptin 234 substantially inhibited kisspeptin-10 stimulation of inositol phosphate, with an IC50 value of 7 nM. At the doses of 1, 10 and 100 nM, kisspeptin 234 significantly reduced kisspeptin-10-induced GnRH neuron firing activity.
Animal experiment:[1]
Animal models	Pubertal female rhesus monkeys
Dosage form	10 nM Infusion of 10 nM kisspeptin 234 over 30 min through a microdialysis probe located in the stalk-median eminence region
Applications	Kisspeptin 234 was shown to reduce pulsatile GnRH secretion in female pubertal monkeys, which supports a key role of kisspeptin in puberty onset.
Note	The technical data provided above is for reference only.
	References: 1. Roseweir AK, Kauffman AS, Smith JT, et al. Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation. Journal of Neuroscience, 2009, 29(12): 3920-3929.