丹参素（钠盐）是来自广泛使用的中药丹参的丹参素的钠盐。
| Cas No. | 67920-52-9 |
| 别名 | 丹参素钠; Sodium Danshensu; (±)-DanShenSu sodium sal |
| 化学名 | sodium;3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate |
| Canonical SMILES | C1=CC(=C(C=C1CC(C(=O)[O-])O)O)O.[Na+] |
| 分子式 | C9H10O5.Na |
| 分子量 | 221.04 |
| 溶解度 | ≥ 22.1mg/mL in Water with gentle warming |
| 储存条件 | Store at 2-8°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Danshensu (sodium salt) is odium salt of danshensu from the widely used Chinese herb Danshen. It can inhibited phenylephrine- and CaCl2-induced vasoconstriction in Ca2+-free medium.In vitro: Sodium danshensu showed a biphasic effects on vessel tension. While low dosage of sodium danshensu produced small contraction possibly through transient enhancement of Ca2+ influx, high dosage produced significant vasodilation mainly through promoting the opening of non-selective K+ channels and small-conductance calcium-sensitive K+ channels in the vascular smooth muscle cells.[1]In vivo: Danshensu did not change the expression of AGEs but partly blocked the increased expression of RAGE in the hippocampus of diabetic mice. Danshensu could ameliorate the cognitive decline in streptozotocin-induced diabetic mice by attenuating advanced glycation end product-mediated neuroinflammation.[2] References:
[1]. Zhang N. Biphasic effects of sodium danshensu on vessel function in isolated rat aorta. Acta Pharmacol Sin, 2010 Apr, 31(4):421-8.
[2]. Tian Wang et al. Danshensu ameliorates the cognitive decline in streptozotocin-induced diabetic mice by attenuating advanced glycation end product-mediated neuroinflammation. J Neuroimmunol, 2012 Apr, 245(1-2):79-86. |
