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Peiminine
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Peiminine图片
CAS NO:18059-10-4
包装:20mg
市场价:1418元

Peiminine (Verticinone; Raddeanine) 是一种具有抗炎活性的天然化合物。
Cas No.18059-10-4
别名贝母素乙,Vertieinon
化学名(3S,4aS,6aS,6bS,8aS,9S,9aS,12S,15aS,15bR,16aS,16bR)-3,9-dihydroxy-9,12,16b-trimethyldocosahydrobenzo[4,5]indeno[1,2-h]pyrido[1,2-b]isoquinolin-5(15bH)-one
分子式C27H43NO3
分子量429.63
溶解度DMF: 10mg/mL,DMSO: 15mg/mL,DMSO:PBS (pH 7.2) (1:30): 0.03mg/mL,Ethanol: 10mg/mL
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Peiminine(Verticinone; Raddeanine) is a natural compound with anti-inflammatory activity.IC50 value:Target:Peiminine and DXS significantly reduced alveolar inflammation and pulmonary interstitial inflammation in rats with bleomycin-induced lung injury. peiminine inhibits lung inflammation and pulmonary fibrosis in a rat model of bleomycin-induced lung injury, by reducing circulating IFN-γ levels and inhibiting signal transduction pathways involving TGF-β, CTGF, ERK1/2, NF-κB and FasL.

References:
[1]. Guo H, et al. Peiminine ameliorates bleomycin-induced acute lung injury in rats. Mol Med Rep. 2013 Apr;7(4):1103-10.

 
 
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