| CAS NO: | 154-93-8 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 询价 |
| 10mg | 询价 |
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 214.05 |
| Cas No. | 154-93-8 |
| Formula | C5H9Cl2N3O2 |
| Solubility | insoluble in H2O; ≥21.51 mg/mL in DMSO; ≥27.15 mg/mL in EtOH |
| Chemical Name | (Z)-N,N'-bis(2-chloroethyl)-N-nitrosocarbamimidic acid |
| Canonical SMILES | ClCC/N=C(O)/N(N=O)CCCl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Carmustine is a nitrogen mustard β-chloro-nitrosourea compound that is used as an antitumor chemotherapeutic agent[1].
In rat glial tumor cytosol and intact cells, carmustine (8, 80, and 800 μM) reduces N-acetyltransferase activities for 2-aminofluorene and p-aminobenzoic acid. In rat glioma cells, carmustine reduces the formation of DNA-AF adducts[1].
Intraperitoneal administration of carmustine 25 mg/kg in rat, which increases liver-to-weight ratio, significantly reduces bile flow, and decreases GSSG and GSH/GSSG values, and mild fibrous edema and monocyte infiltration in the liver of rats[2].
References:
[1].Hung C F. Effects of carmustine and lomustine on arylamine N-acetyltransferase activity and 2-aminofluorene-DNA adducts in rat glial tumor cells. Neurochem Res, 2000, 25(6): 845-51.
[2].Demir A, et al. The effect of trimetazidine on intrahepatic cholestasis caused by carmustine in rats. Hepatol Res, 2001, 20(1): 133-143.
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