2F-Peracetyl-Fucose (1,3,4-Tri-O-acetyl-2-deoxy-2-fluoro-L-fucopyranos) 是一种有效的岩藻糖基转移酶 (FUT) 抑制剂。
| Cas No. | 188783-78-0 |
| 别名 | 2,6-二脱氧-2-氟-L-吡喃半乳糖三乙酸酯,1,3,4-Tri-O-acetyl-2-deoxy-2-fluoro-L-fucopyranos |
| Canonical SMILES | O=C(C)O[C@@H]([C@H]([C@@H]1F)OC(C)=O)[C@@H](OC1OC(C)=O)C |
| 分子式 | C12H17FO7 |
| 分子量 | 292.3 |
| 溶解度 | Chloroform: soluble,Methanol: soluble,DMSO: 10 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 2F-Peracetyl-fucose is an inhibitor of protein fucosylation.[1] It inhibits fucosylation of IgG1 monoclonal antibodies produced by CHO-DG44 cells when used at a concentration of 50 µM. It reduces intracellular GDP-fucose levels in CHO-DG44 cells in a concentration-dependent manner. 2F-Peracetyl-fucose (100 µM) also decreases intracellular fucose levels in A. thaliana seedlings.[2] 2F-Peracetyl-fucose decreases root length in A. thaliana seedlings in a concentration-dependent manner. Reference:
[1].Okeley, N.M., Alley, S.C., Anderson, M.E., et al.Development of orally active inhibitors of protein and cellular fucosylationProc. Natl. Acad. Sci. USA110(14)5404-5409(2013)
[2].Villalobos, J.A., Yi, B.R., and Wallace, I.S.2-Fluoro-L-fucose is a metabolically incorporated inhibitor of plant cell wall polysaccharide fucosylationPLoS One10(9)e0139091(2015) |
