Genipin

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Genipin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

6902-77-8

包装与价格：

包装	价格(元)
10mM (in 1mL DMSO)	询价
20mg	询价
100mg	询价

化学性质

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	226.23
Cas No.	6902-77-8
Formula	C₁₁H₁₄O₅
Solubility	≥101.6 mg/mL in EtOH; ≥5.97 mg/mL in H2O; ≥9.8 mg/mL in DMSO
Chemical Name	methyl (1R,4aS,7aS)-1-hydroxy-7-(hydroxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylate
Canonical SMILES	O[C@@H]1OC=C(C(OC)=O)[C@@H]2[C@H]1C(CO)=CC2
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Genipin对丙型肝炎病毒的IC50值为88.41 μM。

Genipin从栀子果实中被提取而得，在中医学上常被用于治疗2型糖尿病症状。

体外实验：Genipin呈时间与剂量依赖性地促进葡萄糖摄取。Genipin促进葡萄糖转运蛋白4转移到肌管细胞表面。在C2C12肌管细胞细胞质中，Genipin提升ATP水平，关闭KATP通道，最终增加钙离子浓度。此外，Wortmannin和钙离子螯合剂EGTA（两种PI3-K抑制剂）能阻断Genipin诱导的葡萄糖摄取。在C2C12肌管细胞中，Genipin提升活性氧与ATP水平[1]。

体内：向大鼠肝注入Genipin后，测定Mrp2底物胆汁分泌量、亚细胞定位以及Mrp2 mRNA水平。结果表明，在CMV中，Genipin增加Mrp2蛋白含量，而非mRNA水平。在Mrp2缺陷型大鼠中，没有观察到上述效果。此外，在经Genipin处理的肝组织切片中，观察到胆小管膜与微绒毛上的Mrp2密度显著增加[2]。

临床试验：N/A。

参考文献：
[1] Ma CJ, Nie AF, Zhang ZJ, Zhang ZG, Du L, Li XY, Ning G. Genipin stimulates glucose transport in C2C12 myotubes via an IRS-1 and calcium-dependent mechanism. J Endocrinol. 2013 Feb 25;216(3):353-62.
[2] Shoda J, Miura T, Utsunomiya H, Oda K, Yamamoto M, Kano M, Ikegami T, Tanaka N, Akita H, Ito K, Suzuki H, Sugiyama Y. Genipin enhances Mrp2 (Abcc2)-mediated bile formation and organic anion transport in rat liver. Hepatology. 2004 Jan;39(1):167-78.

试验操作

Cell experiment:[1]
Cell lines	C₂C₁₂myotubes
Reaction Conditions	0 ~ 100 μM genipin for 0 ~ 24 h incubation
Applications	Genipin stimulated glucose uptake in a time- and dose-dependent manner, with the maximal effect achieved at 2 h with a concentration of 10 μM. In myotubes, genipin promoted glucose transporter 4 (GLUT4) translocation to the cell surface.
Animal experiment:[2]
Animal models	Male Sprague Dawley rats, 180 ~ 220 g
Dosage form	100 mg/kg per day Administered orally for 7 days
Applications	Genipin treatment resulted in significant increases in the basal bile flow and rate of biliary secretion of glutathione (GSH). A substantial increase in the hepatic GSH concentration was also observed in genipin-treated group, whereas the serum GSH concentration was not affected by the treatment.
Note	The technical data provided above is for reference only.
	References: 1. Ma CJ, Nie AF, Zhang ZJ, et al. Genipin stimulates glucose transport in C2C12 myotubes via an IRS-1 and calcium-dependent mechanism. Journal of Endocrinology, 2013, 216(3): 353-362. 2. Shoda J, Miura T, Utsunomiya H, et al. Genipin enhances Mrp2 (Abcc2)-mediated bile formation and organic anion transport in rat liver. Hepatology, 2004, 39(1): 167-178.