7-Ethyl-10-hydroxycamptothecin

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

86639-52-3

包装与价格：

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	392.4
Cas No.	86639-52-3
Formula	C₂₂H₂₀N₂O₅
Solubility	insoluble in H2O; insoluble in EtOH; ≥11.15 mg/mL in DMSO
Canonical SMILES	O[C@@]1(CC)C2=C(COC1=O)C(N(CC3=C4N=C(C=C5)C(C=C5O)=C3CC)C4=C2)=O
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

Extracted from Camptotheca acuminata Decne. fruit, leaf, branch;Store the product in sealed, cool and dry condition

Cell experiment:[1]
Cell lines	The parental human colon cancer cell line KM12C and its two highly metastatic derivatives KM12SM and KM12L4a
Reaction Conditions	2.5 μg/ml 7-ethyl-10-hydroxycamptothecin for 4, 24 or 48 h incubation
Applications	The exposure of the cells to 7-ethyl-10-hydroxycamptothecin induced S-phase and G2 arrest and the KM12L4a cells had the highest response in a time-dependent manner. The rates of apoptosis in the KM12SM and KM12L4a cell lines were increased time-dependently, though there was no such change in the KM12C cells. In conclusion, the effect of 7-ethyl-10-hydroxycamptothecin on the colon cancer cell lines was mediated via conducting S-phase and G2 arrest and apoptosis. This effect was found in the cell lines with higher metastatic potentials, indicating that 7-ethyl-10-hydroxycamptothecin can be used to treat advanced colon cancers.
Note	The technical data provided above is for reference only.
	References: 1. Wallin A, Svanvik J, Holmlund B, et al. Anticancer effect of SN-38 on colon cancer cell lines with different metastatic potential. Oncology Reports, 2008, 19(6): 1493-1498.

Description	7-Ethyl-10-hydroxycamptothecin is an inhibitor of DNA topoisomerase I with IC50 value of 77 nM.
Targets	DNA topoisomerase I
IC50	77 nM