| CAS NO: | 179386-44-8 |
| Cas No. | 179386-44-8 |
| 别名 | U-95666E; PNU-95666 |
| Canonical SMILES | O=C1NC2=C3N1C[C@H](NC)CC3=CC=C2.O=C(/C=C\C(O)=O)O |
| 分子式 | C15H17N3O5 |
| 分子量 | 319.31 |
| 溶解度 | DMSO: 50 mg/mL (156.59 mM); Water: 10 mg/mL (31.32 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Sumanirole maleate(PNU 95666E; U95666E) is a highly selective D2 receptor full agonist with an ED50 of about 46 nM.IC50 value: 46 nM (EC50)Target: D2 receptorSumanirole was developed for the treatment of Parkinson's disease and restless leg syndrome. While it has never been approved for medical use. Sumanirole is a highly valuable tool compound for basic research to identify neurobiological mechanisms that are based on a dopamine D2-linked (vs. D1, D3, D4, and D5-linked) mechanism of action. [1]. Arthur G. Romero, et al. Synthesis of the Selective D2 Receptor Agonist PNU-95666E fromD-Phenylalanine Using a Sequential Oxidative CyclizationStrategy. J. Org. Chem. 1997, 62, 6582-6587 |
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