Semilicoisoflavone B

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

129280-33-7

Semilicoisoflavone B，一种异黄酮，主要来源于 Glycyrrhiza uralensis Fisch.。Semilicoisoflavone B 通过抑制 β-分泌酶-1 (BACE1) 的表达和活性来减少淀粉样蛋白 β (amyloid β，Aβ) 的分泌。Semilicoisoflavone B 主要通过增加 PPARγ 表达和抑制 STAT3 磷酸化来降低 BACE1 的表达。

Cas No.	129280-33-7
别名	半甘草异黄酮 B
Canonical SMILES	O=C1C(C2=CC(O)=C3C(C=CC(C)(C)O3)=C2)=COC4=CC(O)=CC(O)=C14
分子式	C₂₀H₁₆O₆
分子量	352.34
溶解度	Soluble in DMSO
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Semilicoisoflavone B, an isoflavone, mainly derived from Glycyrrhiza uralensis Fisch.. Semilicoisoflavone B reduces amyloid β (Aβ) secretion by inhibiting β-secretase-1 (BACE1) expression and activity. Semilicoisoflavone B decreases BACE1 expression mainly through increasing PPARγ expression and inhibiting STAT3 phosphorylation[1]. [1]. Gu MY, et al. Glycyrrhiza uralensis and Semilicoisoflavone B Reduce Aβ Secretion by Increasing PPARγ Expression and Inhibiting STAT3 Phosphorylation to Inhibit BACE1 Expression. Mol Nutr Food Res. 2018 Mar;62(6):e1700633.