Roquefortine C 是从 Penicillium roquefortii 中分离出来的一种真菌环肽，可激活 P-gp 并抑制 P450-3A 和其他血红蛋白。
| Cas No. | 58735-64-1 |
| 别名 | 异烟棒曲霉素 C |
| 化学名 | (3E,5aS,10bR)-10b-(1,1-dimethyl-2-propen-1-yl)-6,10b,11,11aS-tetrahydro-3-(1H-imidazol-5-ylmethylene)-2H-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4(3H,5aH)-dione |
| Canonical SMILES | CC([C@]12C3=CC=CC=C3N[C@]1(N([C@@]([H])(C2)C(N/4)=O)C(C4=C/C5=CN=CN5)=O)[H])(C=C)C |
| 分子式 | C22H23N5O2 |
| 分子量 | 389.5 |
| 溶解度 | DMF: Soluble,DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Roquefortine C is a mycotoxin that was first isolated from a strain of P. roqueforti, a species of Penicillium commercially used to ripen blue-veined cheeses. It has also been isolated from other members of the Penicillium genus found in contaminated food products where it displays neurotoxic properties. It has been shown to both activate a P-glycoprotein transport system involved in the efflux of xenobiotics and to inhibit cytochrome P450 3A detoxification enzymes. It has also been used as a biomarker for penitrem A intoxication. |
