Ftase inhibitor I (B581) 是一种有效的、选择性的肽模拟法尼基转移酶 (FTase) 抑制剂。 Ftase 抑制剂 I 对 FTase 的选择性优于香叶基香叶基类异戊二烯 (Ras-GG) 或脂肪酸肉豆蔻酸酯 (Myr-Ras)。
| Cas No. | 149759-96-6 |
| 别名 | N-[(2S)-((2R)-2-氨基-3-巯基丙基氨基)-3-甲基丁基]-L-苯丙氨酰-L-蛋氨酸,B581 |
| 化学名 | N-[(2S)-2-[[(2R)-2-amino-3-mercaptopropyl]amino]-3-methylbutyl]-L-phenylalanyl-L-methionine |
| Canonical SMILES | O=C(N[C@H](C(O)=O)CCSC)[C@@H](NC[C@H](C(C)C)NC[C@@H](N)CS)CC1=CC=CC=C1 |
| 分子式 | C22H38N4O3S2 |
| 分子量 | 470.7 |
| 溶解度 | Water: Soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | FTase inhibitor I is a potent inhibitor of farnesyltransferase (FTase; IC50 = 21 nM) that is greater than 30-fold selective for FTase over geranylgeranyl transferase (GGTase; IC50 = 790 nM). It prevents farnesylation of Ras and inhibits proliferation of cells transformed by Ras farnesylation. In a dog model of subarachnoid hemorrhage, it reduces GTP-Ras in spastic basilar arteries, decreases angiographic vasospasm, and improves clinical scores. |
