首页 蛋白库 基因库 产品 会员服务
位置：首页 > 产品库 > Bafilomycin D
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
Bafilomycin D
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Bafilomycin D图片
CAS NO:98813-13-9
包装与价格：
包装价格(元)
1mg询价
5mg询价

vacuolar H+ ATPases (V-ATPases) inhibitor
Cas No.98813-13-9
别名巴佛洛霉素D
化学名(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-16-[(1S,2R,3S,5E,7S,8R)-2,8-dihydroxy-1,3,7,9-tetramethyl-4-oxo-5-decen-1-yl]-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-oxacyclohexadeca-3,5,11,13-tetraen-2-one
Canonical SMILESC[C@H](C(/C=C/[C@H](C)[C@H](O)C(C)C)=O)[C@H](O)[C@@H]([C@](OC(/C(OC)=C/C(C)=C/[C@@H](C)[C@@H](O)[C@@H](C)C1)=O)([H])[C@H](/C=C/C=C1\C)OC)C
分子式C35H56O8
分子量604.8
溶解度Soluble in ethanol;Soluble in methanol;Soluble in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Bafilomycin D is a potent inhibitor of vacuolar H+ ATPases (V-ATPases) with IC50 value of approximately 2 nM for the V-ATPase from the fungus N. crassa [1].

Ion pumps use the energy provided by the hydrolysis of ATP to energize ion-transport processes across cell membranes. ATPases can be distinguished to P-type, F-type and V-type ATPases. P-type ATPases have a phosphorylated transitional stage, F-type ATPases are primarily used in ATP synthesis, and V-type ATPases are genetically and functionally related to F-ATPases but function only in ATP breakdown [1].

The bafilomycins are fungal plecomacrolide class macrolide antibiotics isolated from the culture medium of Streptomyces sp. and are also high-affinity inhibitors of V-ATPases and can be used to study specifically the function of this type of ATPase. They inhibited the growth of Gram-positive bacteria and fungi. Bafilomycin C1 inhibited the enzymatic activity of the Na+, K+-ATPase with Ki value of 11 μmol/l and showed anthelmintic activity against Caenorhabditis elegans [1][2].

References:
[1].  Drse S, Altendorf K. Bafilomycins and concanamycins as inhibitors of V-ATPases and P-ATPases. J Exp Biol. 1997 Jan;200(Pt 1):1-8.
[2].  Bowman EJ, Siebers A, Altendorf K. Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells. Proc Natl Acad Sci U S A. 1988 Nov;85(21):7972-6.

 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024