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Oligomycin C
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Oligomycin C图片
CAS NO:11052-72-5
包装与价格：
包装价格(元)
1mg询价
5mg询价

Oligomycin C 是一种由链霉菌属菌株产生的大环内酯类抗生素。
Cas No.11052-72-5
别名寡霉素C
化学名(1R,2'R,4E,5'S,6S,6'S,7R,8S,10R,11S,12S,14S,15S,16R,18E,20E,22R,25S,28S,29R)-22-ethyl-3',4',5',6'-tetrahydro-7,11,15-trihydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-spiro[2,26-dioxab
Canonical SMILESO=C([C@@H](C)[C@H](O)[C@@H](C)/C=C/1)[C@H](C)[C@@H](O)[C@H](C)C([C@@H](C)[C@@H](O)[C@H](C)C/C=C/C=C/[C@@](CC)([H])CC[C@@]2([H])[C@@H](C)[C@@]([C@H](C)[C@@]3(CC[C@H](C)[C@@](C[C@H](O)C)([H])O3)O2)([H])OC1=O)=O
分子式C45H74O10
分子量775.1
溶解度DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Oligomycins are the macrolide antibiotics produced by Streptomyces species such as Streptomyces diastatochromogenes, S. libani and S. avermitilis. Oligomycins exihibited a strong toxicity against other organisms, such as Aspergillus niger, Alternaria alternata, Botrytis cinerea and Phytophthora capsici. Oligomycins showed no activity towards bacteria. Different oligomycin isomers are highly specific for the disruption of mitochondrial metabolism.

Oligomycin C is a minor antifungal compound isolated from Streptomyces strain in soil sample that acts as an inhibitor of the mitochondrial F1FO-ATP synthase [1]. Inhibition of the ATP synthase by oligomycins resulted in cell death [2].

References:
[1].  Yang P W, Li M G, Zhao J Y, et al. Oligomycins A and C, major secondary metabolites isolated from the newly isolated strain Streptomyces diastaticus[J]. Folia microbiologica, 2010, 55(1): 10-16.
[2].  Marton A, Mihalik R, Bratincsák A, et al. Apoptotic cell death induced by inhibitors of energy conservation[J]. European journal of biochemistry, 1997, 250(2): 467-475.

 
 
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