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N-(p-amylcinnamoyl)Anthranilic Acid
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
N-(p-amylcinnamoyl)Anthranilic Acid图片
CAS NO:110683-10-8
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)询价
25mg询价
50mg询价
100mg询价

N-(p-amylcinnamoyl) Anthanilic Acid (ACA) 是一种广谱磷脂酶 A2 (PLA2) 抑制剂和 TRP 通道阻滞剂。
Cas No.110683-10-8
别名2-(3-(4-戊基苯基)丙烯酰胺基)苯甲酸,ACA
化学名2-((Z)-((E)-1-hydroxy-3-(4-pentylphenyl)allylidene)amino)benzoic acid
Canonical SMILESCCCCCC1=CC=C(/C([H])=C([H])/C(O)=N/C2=CC=CC=C2C(O)=O)C=C1
分子式C21H23NO3
分子量337.41
溶解度≥ 33.7mg/mL in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is a broad-spectrum phospholipase A2 (PLA2) inhibitor and TRP channel blocker [1] [2].

PLA2 enzymes are a family of structurally different enzymes including at least nine subfamilies. The mammalian TRP proteins including at least 27 members and can be grouped into TRPC, TRPV, TRPM, TRPA, TRPP, and TRPML six subfamilies [1].

N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is a broad-spectrum PLA2 inhibitor and TRP channel blocker [1] [2]. In HEK293 cells transfected with human TRPM2, ACA (20 ?M) completely blocked H2O2-induced Ca2+ signals and ADPR-induced whole-cell currents with IC50 value of 1.7 ?M. ACA (20 ?M) also blocked human TRPM8-induced Ca2+ signals and TRPC6-mediated currents with IC50 values of 3.9 ?M and 2.3 ?M, respectively. ACA can serve as a useful tool for studying the function of TRPM2 in native cells [2]. In isolated pig cardiac ventricular myocytes, ACA reversibly inhibited ICl(Ca) with IC50 value of 4.2 ?M in a concentration-dependent way. ACA (50 ?M) also inhibited the cAMP-activated chloride current.

References:
[1].Harteneck C, Frenzel H, Kraft R. N-(p-amylcinnamoyl)anthranilic acid (ACA): a phospholipase A(2) inhibitor and TRP channel blocker. Cardiovasc Drug Rev. 2007 Spring;25(1):61-75.
[2].Kraft R, Grimm C, Frenzel H, et al. Inhibition of TRPM2 cation channels by N-(p-amylcinnamoyl)anthranilic acid. Br J Pharmacol. 2006 Jun;148(3):264-73.
[3].Gwanyanya A, Macianskiene R, Bito V, et al. Inhibition of the calcium-activated chloride current in cardiac ventricular myocytes by N-(p-amylcinnamoyl)anthranilic acid (ACA). Biochem Biophys Res Commun. 2010 Nov 19;402(3):531-6.

 
 
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