7ACC2 是一种有效的单羧酸转运蛋白 (MCT) 抑制剂，抑制 [14C]-乳酸流入的 IC50 为 11 nM。 7ACC2 也是线粒体丙酮酸转运的有效抑制剂。 7ACC2 是一种通过抑制乳酸通量的抗癌剂。
| Cas No. | 1472624-85-3 |
| 化学名 | [(1aS,2S,7aS)-1a,2,7,7a-tetrahydro-1H-cyclopropa[b]naphthalen-2-yl] 4-nitrobenzoate |
| Canonical SMILES | C1C2C1C(C3=CC=CC=C3C2)OC(=O)C4=CC=C(C=C4)[N+](=O)[O-] |
| 分子式 | C18H15NO4 |
| 分子量 | 309.32 |
| 溶解度 | DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 0.5 mg/ml |
| 储存条件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 7ACC2 is a new potent MCT inhibitor with IC50 of 11 nM for inhibition of [14C]-lactate influx; new antitumor treatment targeting lactate transport in cancer cells.IC50 value: 11 nM ([14C]-lactate influx) [1]Target: MCT inhibitor; lactate transport inhibitor7ACC2 did not influence the prothrombin time which, together with a good in vitro ADME profile, supports the potential of this new family of compounds to act as anticancer drugs through inhibition of lactate flux. References:
[1]. Draoui N, et al. Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells. Bioorg Med Chem. 2013 Nov 15;21(22):7107-17. |
