化学性质
| Storage | Store at -20°C |
| M.Wt | 411.89 |
| Formula | C20H22ClN7O |
| Solubility | ≥49 mg/mL in EtOH; ≥51.8 mg/mL in H2O; ≥53.4 mg/mL in DMSO |
| Chemical Name | (R)-3-methyl-4-(4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridin-2-yl)morpholine hydrochloride |
| Canonical SMILES | C[C@H](COCC1)N1C2=CC(C3=CC=NN3C)=C4C(C(C5=CC=NN5)=NC=C4)=N2.Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
资料参考
BAY-1895344 is a potent and selective ATM inhibitor with IC50 of 7 nM. BAY 1895344 shows strong anti-tumor efficacy in monotherapy and forms a strong combined potential with the targeted alpha therapy Radium-223 dichloride.BAY 1895344 has no activity in hERG patch-clamp assay. In the tumor model of DNA damage defects, BAY 1895344 single drug administration or combined treatment with other DNA damage-inducing therapies have good efficacy.
