Indoxyl Sulfate(potassium salt)

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CAS NO:

2642-37-7

包装与价格：

包装	价格(元)
100mg	询价
250mg	询价
500mg	询价
1g	询价

化学性质

Physical Appearance	A crystalline solid
Storage	Store at -20°C
M.Wt	251.3
Cas No.	2642-37-7
Formula	C₈H₆KNO₄S
Solubility	insoluble in EtOH; ≥25.15 mg/mL in H2O; ≥51.9 mg/mL in DMSO
Chemical Name	potassium 1H-indol-3-yl sulfate
Canonical SMILES	[O-]S(OC1=CNC2=CC=CC=C21)(=O)=O.[K+]
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Indoxyl sulfate is a metabolite of tryptophan derived from dietary protein. In chronic kidney disease patients where renal function is compromised, indoxyl sulfate can accumulate in serum as a uremic toxin, inducing oxidative stress and accelerating progression of the disease[1]. Indoxyl sulfate at 250 μM can induce the activation of NF-κB, promoting the expression of both TGF-β1 and Smad3 expression in proximal tubular cells of rats, which is associated with profibrotic activity[2].

References：

[1]. Niwa T. Uremic toxicity of indoxyl sulfate. Nagoya J.Med.Sci, 2010, 72(1-2): 1-11.

[2]. Shimizu H, Yisireyili M, Nishijima F, et al. Indoxyl sulfate enhances p53-TGF-β1-Smad3 pathway in proximal tubular cells. Am.J.Nephrol, 2013, 37(2): 97-103.