6β-hydroxy Testosterone

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CAS NO:	62-99-7
包装:	5mg
市场价:	1330元

化学性质

Physical Appearance	A crystalline solid
Storage	Store at -20°C
M.Wt	304.42
Cas No.	62-99-7
Formula	C₁₉H₂₈O₃
Solubility	≤1mg/ml in acetonitrile;1mg/ml in ethanol;1mg/ml in methanol
Chemical Name	(6R,8R,9S,10R,13S,14S,17S)-6,17-dihydroxy-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
Canonical SMILES	C[C@]12[C@]([H])([C@@]3(C[C@H](C4=CC(CC[C@@]4([C@]3(CC2)[H])C)=O)O)[H])CC[C@@H]1O
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

CYP3A4 and CYP3A5 are cytochrome P450 enzymes whose expression is induced by glucocorticoids and certain xenobiotics, including many drugs and chemical carcinogens[1]. They mediate the metabolism of xenobiotics and certain intrinsic biotin, including steroid hormones[2].

6β-hydroxytestosterone is the main metabolite produced from testosterone through the action of CYP3A4 and CYP3A5, accounting for 75-80% of all metabolites formed by testosterone[2,3].

References:

[1]. Cooper B W, Cho T M, Thompson P M, et al. Phthalate induction of CYP3A4 is dependent on glucocorticoid regulation of PXR expression. Toxicological Sciences, 2008, 103(2): 268-277.

[2]. Draper A J, Madan A, Smith K, et al. Development of a non-high pressure liquid chromatography assay to determine testosterone hydroxylase (CYP3A) activity in human liver microsomes. Drug Metabolism and Disposition, 1998, 26(4): 299-304.

[3]. Capdevila J H, Karara A, Waxman D J, et al. Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase. The Journal of Biological Chemisty, 1990, 265: 10865-10871.