3-Bromopyruvic acid

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3-Bromopyruvic acid

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1113-59-3

包装与价格：

包装	价格(元)
1g	询价
5g	询价
10g	询价
25g	询价

化学性质

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	166.96
Cas No.	1113-59-3
Formula	C₃H₃BrO₃
Synonyms	Bromopyruvic acid; Hexokinase II Inhibitor II, 3-BP
Solubility	≥16.7 mg/mL in H2O; ≥23.55 mg/mL in DMSO; ≥49.5 mg/mL in EtOH
Chemical Name	3-bromo-2-oxopropanoic acid
Canonical SMILES	BrCC(C(O)=O)=O
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

3-Bromopyruvic acid (3-BP) is a hexokinase II inhibitor with Ki of 2.4 mM, is an effective antitumor agent on the hepatoma cells[1].

3-BP decreases proliferation of hepatocellular carcinoma BEL-7402 cells that express hexokinase II, an isoform of hexokinase overexpressed in many cancers[2,3].

3-BP reduces tumor growth and induces tumor necrosis in a hepatocellular carcinoma mouse xenograft model when administered at a dose of 50 mg/kg per day, six days per week, for three weeks[2].

References：

[1]. Ihrlund L S, Hernlund E, Khan O, et al. 3-Bromopyruvate as inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs. Molecular Oncology, 2008, 2(1): 94-101.

[2]. Gong L, Wei Y, Yu X, et al. 3-Bromopyruvic acid, a hexokinase II inhibitor, is an effective antitumor agent on the hepatoma cells: In vitro and in vivo findings. Anticancer Agents Med. Chem, 2014, 14(5): 771-776.

[3]. Lis P, Dylag M, Niedzwiecka K, et al. The HK2 dependent "Warburg Effect" and mitochondrial oxidative phosphorylation in cancer: Targets for effective therapy with 3-bromopyruvate. Molecules, 2016, 21(12): E1730.