(±)trans-2,5-bis-(3,4,5-Trimethoxyphenyl)-1,3-dioxolane

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CAS NO:

116673-45-1

包装与价格：

包装	价格(元)
5mg	询价
10mg	询价

化学性质

Physical Appearance	A crystalline solid
Storage	Store at -20°C
M.Wt	406.4
Cas No.	116673-45-1
Formula	C₂₁H₂₆O₈
Synonyms	trans-BTP Dioxolane
Solubility	≤35mg/ml in ethanol;50mg/ml in DMSO;50mg/ml in dimethyl formamide
Chemical Name	trans-(±)-2,4-bis(3,4,5-trimethoxyphenyl)-1,3-dioxolane
Canonical SMILES	COC1=CC([C@H]2O[C@H](C3=CC(OC)=C(OC)C(OC)=C3)OC2)=CC(OC)=C1OC
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

(±)trans-2,5-bis-(3,4,5-Trimethoxyphenyl)-1,3-dioxolane, also known as trans-BTP Dioxolane, is a PAF receptor antagonist [1].

Platelet activating factor (PAF), a phospholipid mediator of inflammation, is secreted by several cell types including arterial endothelial cells, and can activate polymorphonuclear leucocytes and monocytes via specific cell surface receptors. PAF also stimulates the production of active oxygen species by human monocyte - derived macrophages. PAF play important roles in a variety of pathophysiological states including acute allergy, inflammation, asthma, gastrointestinal ulceration, and toxic shock [1].

(±)trans-2,5-bis-(3,4,5-Trimethoxyphenyl)-1,3-dioxolane is a PAF receptor antagonist. In the rabbit washed platelet assay, (±)trans-2,5-bis-(3,4,5-Trimethoxyphenyl)-1,3-dioxolane showed good competitive PAF antagonism with Ki value of 0.3 μM, whereas the cis-isomer was much less active.

Reference:
[1]. Corey, E.J.,Chen, C.P., and Parry, M.J. Dual binding modes to the receptor for platelet activating factor (PAF) of anti-PAF trans-2,5-diarylfurans. Tetrahedron Letters 29, 2899-2902 (1988).