Actagardin

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Actagardin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

59165-34-3

包装与价格：

包装	价格(元)
1mg	询价
5mg	询价

化学性质

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	1890.2
Cas No.	59165-34-3
Formula	C₈₁H₁₂₄N₂₀O₂₄S₄
Synonyms	Antibiotic A 3802-IV-3,Gardimycin
Solubility	Soluble in ethanol;methanol;DMSO;dimethyl formamide
Chemical Name	D-cysteinyl-L-serylglycyl-L-tryptophyl-L-valyl-L-cysteinyl-(2S,3S)-2-amino-3-mercaptobutanoyl-L-leucyl-(2S,3S)-2-amino-3-mercaptobutanoyl-L-isoleucyl-L-a-glutamyl-L-cysteinylglycyl-(2S,3S)-2-amino-3-mercaptobutanoyl-L-valyl-L-isoleucyl-L-cysteinyl-L-alany
Canonical SMILES	O=C(CN1)N[C@@H](CC2=CNC3=C2C=CC=C3)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@H]([C@H](C)SC[C@](C(NCC(N[C@@]([C@@H]4C)([H])C(N[C@@H](C(C)C)C(N[C@@]5([H])[C@@H](C)CC)=O)=O)=O)=O)([H])NC6=O)C(N[C@@H](CC(C)C)C(N[C@](C(N[C@]([C@@H](C)CC)([H])C(N[C@H]6CCC(O)=O)=O)=O)
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Actagardin is a tetracyclic antibiotic.

Actagardin is a tetracyclic antibiotic produced by several species of Actinoplanes.

In vitro: During the repeated fermentations of actagardin, two new compounds, named D and E, were isolated. Compound D was found to be twice as active as actagardin against Streptococcus pyogenes C 203 and four times more active than actagardin against Staphylococcus aureus ATCC 6538, S. pneumoniae UC 41, and S. aureus TOUR in the in-vitro tests [1].

In vivo: Animal study showed that compound D was also more effective than the parent compound actagardin against experimental infections in mice with either S. pyogenes C 203 or S. aureus TOUR, after sc administration. However, compound D was ineffective at doses up to 150 mg/kg when given orally to mice infected with S. pyogenes C 203. Moreover, compound D (LD50 1,250 mg/kg, mice, ip) was about 2.5 times more toxic than actagardine (3,310 mg/kg). In addition, compound E showed practically no in vitro activity up to 50 μg/ml against the tested organisms [1].

Clinical trial: So far, no clinical study has been conducted.

Reference:
[1] Malabarba A, Landi M, Pallanza R, Cavalleri B. Physico-chemical and biological properties of actagardine and some acid hydrolysis products. J Antibiot (Tokyo). 1985 Nov;38(11):1506-11.