Z-Asp-CH2-DCB

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Z-Asp-CH2-DCB

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

153088-73-4

包装与价格：

包装	价格(元)
5mg	询价
10mg	询价
25mg	询价
50mg	询价

化学性质

Physical Appearance	A crystalline solid
Storage	Store at -20°C
M.Wt	454.3
Cas No.	153088-73-4
Formula	C₂₀H₁₇Cl₂NO₇
Synonyms	Z-Asp-2,6-Dichlorobenzoyloxymethyl Ketone
Solubility	≤33mg/ml in ethanol;25mg/ml in DMSO;25mg/ml in dimethyl formamide
Chemical Name	(3S)-4-carboxy-2-oxo-3-[[(phenylmethoxy)carbonyl]amino]butyl ester 2,6-dichloro-benzoic acid
Canonical SMILES	ClC1=C(C(OCC([C@@H](NC(OCC2=CC=CC=C2)=O)CC(O)=O)=O)=O)C(Cl)=CC=C1
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Z-Asp-CH2-DCB is an inhibitor of ICE/Ced-3 family proteases [1].

Caspases (ICE/ Ced3 proteases) play key biological roles in inflammation and mammalian apoptosis. Caspases are a closely related family of cysteine proteases that play a key role in apoptotic cell death. Activation of Caspases shows important roles in programmed cell death such as pyroptosis and necroptosis to protect cells from stress signals and pathogenic attack. Caspases play an important role in inflammation. Caspases have also been involved in cell proliferation, cell differentiation, tumour suppression, neural development and axon guidance and ageing. Deficiency in caspase results in tumour development. Overactivation of some caspases can lead to excessive programmed cell death, such as caspase-3 [2].

Z-Asp-CH2-DCB blocked apoptosis in U937 cells triggered by antitumor agents. Z-Asp-CH2-DCB also blocked apoptosis in IFN-γ-pretreated cells. Z-Asp-CH2 -DCB completely inhibited DNA fragmentation induced by γ-irradiation, antitumor agents, or anti-Fas antibody [1].

References:
[1] Tamura T, Ueda S, Yoshida M, et al. Interferon-γ InducesIceGene Expression and Enhances Cellular Susceptibility to Apoptosis in the U937 Leukemia Cell Line[J]. Biochemical and biophysical research communications, 1996, 229(1): 21-26.
[2] Brker L E, Kruyt F A E, Giaccone G. Cell death independent of caspases: a review[J]. Clinical Cancer Research, 2005, 11(9): 3155-3162.