L-Biopterin

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L-Biopterin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

22150-76-1

包装与价格：

包装	价格(元)
10mg	询价
25mg	询价
50mg	询价

化学性质

Physical Appearance	A crystalline solid
Storage	Store at -20°C
M.Wt	237.2
Cas No.	22150-76-1
Formula	C₉H₁₁N₅O₃
Synonyms	L-erythro-Biopterin,NSC 339699
Solubility	insoluble in EtOH; insoluble in H2O; ≥4.55 mg/mL in DMSO with ultrasonic
Chemical Name	2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-4(1H)-pteridinone
Canonical SMILES	NC(N=C1C2=NC([C@@H](O)[C@@H](O)C)=CN1[H])=NC2=O
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

L-Biopterin is the oxidized form of tetrahydrobiopterin (BH4) [1].

Tetrahydrobiopterin (BH4) has been also known as sapropterin. BH4 is an essential cofactor of the three aromatic amino acid hydroxylase enzymes which has used in the degradation of amino acid phenylalanine and in the biosynthesis of the neurotransmitters serotonin (5-HT), melatonin, norepinephrine, dopamine, epinephrine (adrenaline). BH4 is a cofactor of nitric oxide synthases [2].

L-Biopterin was reduced to BH4 via thioredoxin reductase followed by dihydropteridine reductase or reduced glutathione. L-Biopterin was extremely toxic to human melanocytes in culture with the IC50 of 0.2 μM after 48 hrs. L-Biopterin was rarely existed under physiological conditions except in the epidermis of patients with the depigmentation disorder Vitiligo [3].

References:
[1] Schallreuter K U, Buttner G, Pittelkow M R, et al. Cytotoxicity of 6-biopterin to human melanocytes[J]. Biochemical and biophysical research communications, 1994, 204(1): 43-48.
[2] Calka J. The role of nitric oxide in the hypothalamic control of LHRH and oxytocin release, sexual behavior and aging of the LHRH and oxytocin neurons[J]. Folia Histochemica et Cytobiologica, 2006, 44(1): 3.
[3] Moore J, Wood J M, Schallreuter K U. Evidence for Specific Complex Formation between α-Melanocyte Stimulating Hormone and 6 (R)-l-Erythro-5, 6, 7, 8-tetrahydrobiopterin using Near Infrared Fourier Transform Raman Spectroscopy[J]. Biochemistry, 1999, 38(46): 15317-15324.