| CAS NO: | 886-86-2 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 询价 |
| 25g | 询价 |
| 50g | 询价 |
| 100g | 询价 |
| Storage | Store at RT |
| M.Wt | 261.3 |
| Cas No. | 886-86-2 |
| Formula | C9H11NO2·CH4O3S |
| Synonyms | Ethyl m-Aminobenzoate|NSC 93790 |
| Solubility | ≥13.25 mg/mL in DMSO; ≥29.5 mg/mL in EtOH; ≥54.5 mg/mL in H2O |
| Chemical Name | 3-amino-benzoic acid-ethyl ester, monomethanesulfonate |
| Canonical SMILES | O=C(OCC)C1=CC(N)=CC=C1.O=S(O)(C)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Ethyl 3-Aminobenzoate can block the generation of action potentials via voltage-dependent Na+-channels.
Sodium channels play a critical role in physiology: they can rapidly transmit depolarizing impulses throughout cells and cell networks, therefore enabling co-ordination of higher processes. Sodium channels are also of special importance for the history of physiology.
In vitro: The major mode of action for ethyl 3-aminobenzoate was found to be nervous system suppression whereby the entrance of sodium into the nerve was inhibited, therefore limiting nerve membrane excitability. In addition, the nerve inhibition was facilitated by the lipid solubility of ethyl 3-aminobenzoate, which allowed it to move easily into the cell membrane to bind with sodium channels [1].
In vivo: Previous study evaluated the potency and dynamics of ethyl 3-aminobenzoate-induced effects on neuronal firing of sensory and motor nerves alongside a defined motor behavior in Xenopus laevis tadpoles. Electrophysiological recordings of extraocular motor discharge and nerve activity were measured before, during and after administration of drugs. Results showed that ethyl 3-aminobenzoate and benzocaine, but not pancuronium could cause a dose-dependent, reversible blockade of extraocular motor and sensory nerve activity. Such results indicated that ethyl 3-aminobenzoate was able to block the activity of both sensory and motor nerves compatible with the mechanistic action of effective anesthetics, suggesting that ethyl 3-aminobenzoate was effective as single-drug anesthetic for surgical interventions in anamniotes [2].
Clinical trial: So far, no clinical study has been conducted.
References:
[1] K. M. Carter, C. M. Woodley and R. S. Brown. A review of tricaine methanesulfonate for anesthesia of fish. Rev. Fish Biol. Fisheries 21, 51-59 (2011).
[2] C. Ramlochansingh, F. Branoner, B. P. Chagnaud, et al. Efficacy of tricaine methanesulfonate (MS-222) as an anesthetic agent for blocking sensory-motor responses in Xenopus laevis tadpoles. PLoS One 9(7), e101606 (2014).
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