MIK665 (S-64315) (S-64315) 衍生自 S63845，是一种髓细胞白血病序列 1 (MCL1) 抑制剂。 MIK665 (S-64315) 对 MCL1 的 IC50 为 1.81 nM。
| Cas No. | 1799631-75-6 |
| 别名 | S-64315 |
| Canonical SMILES | OC([C@@H](CC(C=CC=C1)=C1OCC2=CC=NC(C3=CC=CC=C3OC)=N2)OC4=C5[C@]([C@]6=C(C)C(Cl)=C(OCCN7CCN(C)CC7)C=C6)=C(C8=CC=C(F)C=C8)SC5=NC=N4)=O |
| 分子式 | C47H44ClFN6O6S |
| 分子量 | 875.41 |
| 溶解度 | DMSO : ≥ 125 mg/mL (142.79 mM);Water :< 0.1 mg/mL (insoluble) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | MIK665 (S-64315) is a special Mcl-1 inhibitor[1]. [1]. Cassier PA, et al. Targeting apoptosis in acute myeloid leukaemia. Br J Cancer. 2017 Oct 10;117(8):1089-1098. |
