Target Protein-binding moiety 13

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CAS NO:

1092369-24-8

Target Protein-binding moiety 13 (PROTAC FKBP12-binding moiety 1) 是 FKBP (SLF) 的合成配体。目标蛋白结合部分 13（PROTAC FKBP12 结合部分 1）可用于 PROTAC 的合成。

Cas No.	1092369-24-8
别名	PROTAC FKBP12-binding moiety 1
Canonical SMILES	O=C(O)CCC(NC1=CC=CC([C@H](OC([C@H]2N(C(C(C(C)(C)CC)=O)=O)CCCC2)=O)CCC3=CC=C(OC)C(OC)=C3)=C1)=O
分子式	C₃₄H₄₄N₂O₉
分子量	624.72
溶解度	Soluble in DMSO
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Target Protein-binding moiety 13 is a synthetic ligand for FKBP (SLF), which is used in the synthesis of PROTACs. Target Protein-binding moiety 13 (SLF building block 2) is a synthetic ligand for FKBP (SLF). SLF is composed of only one half of FK506 and it is known to have a significantly weaker affinity for FKBP12. [1]. Dunyak BM, et al. Selective Targeting of Cells via Bispecific Molecules That Exploit Coexpression of TwoIntracellular Proteins. ACS Chem Biol. 2015 Nov 20;10(11):2441-7.