Cholic acid 7-sulfate (7-Sulfocholic acid) 是胆酸的代谢物，是武田 G 蛋白受体 5 (TGR5) 激动剂。
| Cas No. | 60320-05-0 |
| 别名 | 胆酸7-硫酸盐,7-Sulfocholic acid |
| 化学名 | (3α,5β,7α,12α)-3,12-dihydroxy-7-(sulfooxy)-cholan-24-oic acid |
| Canonical SMILES | C[C@H](CCC(O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@H](OS(O)(=O)=O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@@]21C |
| 分子式 | C24H40O8S |
| 分子量 | 488.6 |
| 溶解度 | 0.3mg/mL in DMSO, 1mg/mL in DMF |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Cholic acid 7-sulfate is a metabolite of the primary bile acid cholic acid.[1],[2] It is produced by conjugation of a sulfate group with the hydroxy group at position 7 of cholic acid in the liver and gut. Fecal levels of cholic acid 7-sulfate are increased in male, but not female, mice fed a diet supplemented with cholic acid or chenodeoxycholic acid.[2] Reference:
[1]. Alnouti, Y. Bile acid sulfation: A pathway of bile acid elimination and detoxification. Toxicological Sciences 108(2), 225-246 (2009).
[2]. Zhang, Y., and Klaassen, C.D. Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in mice. J. Lipid Res. 51(11), 3230-3242 (2010). |
