Triflurdine (Viroptic) (Trifluorothymidine; 5-Trifluorothymidine; TFT) 是一种不可逆的胸苷酸合成酶抑制剂，从而抑制 DNA 合成。 Triflurdine (Viroptic) 是一种用于单纯疱疹病毒 (HSV) 感染的抗病毒药物。三氟胸苷还具有抗正痘病毒活性。
| Cas No. | 70-00-8 |
| 别名 | 曲氟尿苷; Trifluorothymidine; 5-Trifluorothymidine; TFT |
| 化学名 | 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(trifluoromethyl)pyrimidine-2,4-dione |
| Canonical SMILES | C1C(C(OC1N2C=C(C(=O)NC2=O)C(F)(F)F)CO)O |
| 分子式 | C10H11F3N2O5 |
| 分子量 | 296.2 |
| 溶解度 | ≥ 14.45mg/mL in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Trifluridine (Trifluorothymidine; 5-Trifluorothymidine; TFT) is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Trifluridine is an antiviral drug for herpes simplex virus (HSV) infection. References:
[1]. Suzuki N, et al. Mode of action of trifluorothymidine (TFT) against DNA replication and repair enzymes. Int J Oncol. 2011 Jul;39(1):263-70.
[2]. Suzuki N, et al. Trifluorothymidine exhibits potent antitumor activity via the induction of DNA double-strand breaks. Exp Ther Med. 2011 May;2(3):393-397.
[3]. Temmink OH, et al. Irinotecan-induced cytotoxicity to colon cancer cells in vitro is stimulated by pre-incubation withtrifluorothymidine. Eur J Cancer. 2007 Jan;43(1):175-83.
[4]. Okayama T, et al. Involvement of concentrative nucleoside transporter 1 in intestinal absorption of trifluorothymidine, a novel antitumor nucleoside, in rats. J Pharmacol Exp Ther. 2012 Feb;340(2):457-62. |
