Topoisomerase II inhibitor,intracellular ion chelator,cardioprotective agent
| Cas No. | 149003-01-0 |
| 别名 | 右雷佐生盐酸盐; ICRF-187 hydrochloride; ADR-529 hydrochloride; NSC-169780 hydrochloride |
| 化学名 | 4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione;hydrochloride |
| Canonical SMILES | CC(CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2.Cl |
| 分子式 | C11H16N4O4.HCl |
| 分子量 | 304.73 |
| 溶解度 | ≥ 15.24mg/mL in DMSO |
| 储存条件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Dexrazoxane hydrochloride (ICRF-187 hydrochloride) is a cardioprotective agent. References:
[1]. Hasinoff BB. The use of dexrazoxane for the prevention of anthracycline extravasation injury. Expert Opin Investig Drugs. 2008 Feb;17(2):217-23.
[2]. Jones RL. Utility of dexrazoxane for the reduction of anthracycline-induced cardiotoxicity. Expert Rev Cardiovasc Ther. 2008 Nov;6(10):1311-7.
[3]. Lipshultz SE, Scully RE, Lipsitz SR et al. Assessment of dexrazoxane as a cardioprotectant in doxorubicin-treated children with high-risk acute lymphoblastic leukaemia: long-term follow-up of a prospective, randomised, multicentre trial. Lancet Oncol. 2010 Oct;11(10):950-61. |
