ICA 110381 (Compound 16) 是一种 KCNQ2/Q3 钾通道开放剂，用于治疗癫痫。
| Cas No. | 325457-99-6 |
| 化学名 | 4-chloro-N-(6-chloropyridin-3-yl)benzamide |
| Canonical SMILES | ClC1=CC=C(C=C1)C(NC2=CC=C(N=C2)Cl)=O |
| 分子式 | C12H8Cl2N2O |
| 分子量 | 267.11 |
| 溶解度 | <26.71mg/ml in DMSO;<5.34mg/ml in ethanol |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | ICA 110381 (Compound 16) is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy. ICA 110381 is a KCNQ2/Q3 agonist (EC50=0.38 μM) as well as KCNQ1 antagonist (IC50=15 μM)[1]. References:
[1]. Amato G, et al. N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy. ACS Med Chem Lett. 2011 Mar 31;2(6):481-4. |
