NS 11021 是一种有效且特异性的 Ca2+- 激活的大电导 K+ 通道（KCa1.1 通道）激活剂。
| Cas No. | 956014-19-0 |
| 化学名 | 1-(3,5-bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(2H-tetrazol-5-yl)phenyl)thiourea |
| Canonical SMILES | BrC1=CC=C(C(C2=NNN=N2)=C1)NC(NC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=S |
| 分子式 | C16H9BrF6N6S |
| 分子量 | 511.24 |
| 溶解度 | DMF: 15 mg/mL,DMF:PBS (pH 7.2)(1:3): 0.25 mg/mL,DMSO: 10 mg/mL,Ethanol: 0.3 mg/mL |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | NS 11021 is a potent and specific Ca2-activated big-conductance K＋ Channels (KCa1.1 channels) activator. NS 11021 at concentrations above 0.3 μM activates KCa1.1 in a concentration-dependent manner by parallelshifting the channel activation curves to more negative potentials[1]. References:
[1]. Bentzen BH，et al. The small molecule NS11021 is a potent and specific activator of Ca2+-activated big-conductance K+ channels. Mol Pharmacol. 2007 Oct;72(4):1033-44. |
