Corticosterone

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Corticosterone

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CAS NO:

50-22-6

包装与价格：

包装	价格(元)
10mM (in 1mL DMSO)	询价
50mg	询价

化学性质

Physical Appearance	A solid
Storage	Store at RT
M.Wt	346.46
Cas No.	50-22-6
Formula	C₂₁H₃₀O₄
Solubility	insoluble in H2O; insoluble in EtOH; ≥14.5 mg/mL in DMSO
Chemical Name	(8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
Canonical SMILES	O[C@@H]1[C@H]([C@](CC2)(C)C3=CC2=O)[C@@H](CC3)[C@H]4[C@]([C@@H](C(CO)=O)CC4)(C)C1
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Corticosterone is a steroid hormone produced in the cortex of the adrenal glands that binds to both glucocorticoid and mineralocorticoid receptors[1].

Corticosterone, via SGK phosphorylation of GDI at Ser-213, increases the formation of GDI-Rab4 complex, facilitating the functional cycle of Rab4 and Rab4-mediated recycling of AMPARs to the synaptic membrane. It provides a potential mechanism underlying the role of corticosteroid stress hormone in up-regulating excitatory synaptic efficacy in cortical neurons[2].

References:

[1]. Lu NZ, Wardell SE, Burnstein KL, et al. International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: Glucocorticoid, mineralocorticoid, progesterone, and androgen receptors. Pharmacol, 2006, 58(4): 782-797.

[2]. Liu W, Yuen E Y, Yan Z. The Stress Hormone Corticosterone Increases Synaptic α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors via Serum- and Glucocorticoid-inducible Kinase (SGK) Regulation of the GDI-Rab4 Complex. Journal of Biological Chemistry, 2010, 285(9): 6101-6108.