Jasplakinolide

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Jasplakinolide

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

102396-24-7

包装与价格：

包装	价格(元)
50ug	询价
100ug	询价

化学性质

Physical Appearance	An off-white solid
Storage	Store at -20°C
M.Wt	709.67
Cas No.	102396-24-7
Formula	C₃₆H₄₅BrN₄O₆
Solubility	Soluble in DMSO
Chemical Name	(4R,7R,10S,13R,17R,19S,E)-7-((2-bromo-1H-indol-3-yl)methyl)-4-(4-hydroxyphenyl)-8,10,13,15,17,19-hexamethyl-1-oxa-5,8,11-triazacyclononadec-15-ene-2,6,9,12-tetraone
Canonical SMILES	BrC(NC1=CC=CC=C21)=C2C[C@H](C(N[C@@H](C(C=C3)=CC=C3O)CC(O[C@@H](C)C[C@@H](C)C=C(C)C[C@@H](C)C(N[C@H]4C)=O)=O)=O)N(C)C4=O
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Jasplakinolide, a cyclodepsipeptide originally isolated from the marine sponge,Jaspis johnstoni, is a potent inducer of actin polymerization, which also stabilizes pre-formed actin filaments. Jasplakinolide may exert its cytotoxic effect by binding to F-actin. Compared with Ca²⁺-actin, jasplakinolide shows a much greater effect on Mg²⁺-actin, and binds to F-actin competitively with phalloidin with a K_dvalue of ~ 15 nM. Jasplakinolide exhibits both fungicidal and antiproliferative activity. In addition, jasplakinolide is membrane-permeable, which makes it a commonly used tool in cell biology, when actin polymerization or actin filament stabilization has to be achieved.

References:

1. Bubb MR, Senderowicz AM, Sausville EA, et al. Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin. Journal of Biological Chemistry, 1994, 269(21): 14869-14871.

2. Holzinger A. Jasplakinolide: an actin-specific reagent that promotes actin polymerization. Methods in Molecular Biology, 2009, 586: 71-87.