CMPDA 是一种 AMPA 受体的正变构调节剂，对 GluA2i/GluA2o 受体的 EC50 值为 45.4 ± 4.2 nM/63.4 ± 5.6 nM。
| Cas No. | 380607-77-2 |
| 化学名 | N,N'-(1,4-phenylenebis(ethane-2,1-diyl))bis(propane-2-sulfonamide) |
| Canonical SMILES | CC(S(NCCC1=CC=C(CCNS(C(C)C)(=O)=O)C=C1)(=O)=O)C |
| 分子式 | C16H28N2O4S2 |
| 分子量 | 376.53 |
| 溶解度 | DMF: 30mg/mL,DMSO: 30mg/mL,Ethanol: 30mg/mL,PBS (pH 7.2): 10mg/mL |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | CMPDA is a positive allosteric modulator of AMPA receptors with EC50s of 45.4 ± 4.2 nM/63.4 ± 5.6 nM for GluA2i/GluA2o receptor.IC50 value: 45.4 ± 4.2 nM/63.4 ± 5.6 nM(GluA2i/GluA2o) [1]Target: AMPAR modulatorCMPDA was nearly equipotent at modulating the two isoforms of GluA2 receptors, whereas CMPDB displayed a modest preference for the flip splice variant. Similar to CX614, CMPDA slowed the rate of deactivation of GluA2o receptors approximately 2-fold but had no effect on GluA2i receptor deactivation [1]. References:
[1]. Timm DE, et al. Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation. Mol Pharmacol. 2011 Aug;80(2):267-80. |
