ML 277(CID53347902) 是一种新型、有效和选择性的 K(v)7.1 (KCNQ1) 钾通道激活剂，EC50 为 270 nM。
| Cas No. | 1401242-74-7 |
| 别名 | CID-53347902 |
| 化学名 | (R,Z)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carbimidic acid |
| Canonical SMILES | CC1=CC=C(S(N2CCCC[C@]2([H])/C(O)=N/C3=NC(C4=CC=C(OC)C=C4)=CS3)(=O)=O)C=C1 |
| 分子式 | C23H25N3O4S2 |
| 分子量 | 471.59 |
| 溶解度 | DMSO: 5 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | ML277(CID53347902) is a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator with EC50 of 270 nM.IC50 value: 270 nM (EC50) [1]Target: K(v)7.1 activatorML277 was shown to be highly selective against other KCNQ channels (>100-fold selectivity versus KCNQ2 and KCNQ4) as well as against the distantly related hERG potassium channel. References:
[1]. Mattmann ME, et al. Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5936-41. |
