KS 176 是一种有效的选择性乳腺癌耐药蛋白 (BCRP) 多药转运蛋白抑制剂（在 Pheo A 和 Hoechst 33342 测定中，IC50 值分别为 0.59 和 1.39 μM）。对 P-gp 或 MRP1 没有抑制活性。
| Cas No. | 1253452-78-6 |
| 化学名 | N-(4-(2-hydroxyethyl)phenyl)-2-(4-nitrobenzamido)benzamide |
| Canonical SMILES | OCCC1=CC=C(NC(C2=CC=CC=C2NC(C3=CC=C(N(=O)=O)C=C3)=O)=O)C=C1 |
| 分子式 | C22H19N3O5 |
| 分子量 | 405.4 |
| 溶解度 | DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter (IC50 values are 0.59 and 1.39 μM in Pheo A and Hoechst 33342 assays respectively). Displays no inhibitory activity against P-gp or MRP1.IC50 value: 0.59( in Pheo A assay), 1.39 μM (in Hoechst 33342 assay).Target: BCRPThe more detailed information please refer to Compound 9 in the reference. References:
[1]. Pick A, et al. Specific inhibitors of the breast cancer resistance protein (BCRP). ChemMedChem. 2010 Sep 3;5(9):1498-505. |
