Sipatrigine (619C89) 是一种神经保护剂，是一种谷氨酸释放抑制剂、电压依赖性钠通道和钙通道抑制剂，可穿透中枢神经系统。
| Cas No. | 130800-90-7 |
| 别名 | 西帕曲近,619C89; BW 619C89 |
| 化学名 | 2-(4-methylpiperazin-1-yl)-5-(2,3,5-trichlorophenyl)pyrimidin-4-amine |
| Canonical SMILES | ClC(C(C1=CN=C(N=C1N)N2CCN(C)CC2)=CC(Cl)=C3)=C3Cl |
| 分子式 | C15H16Cl3N5 |
| 分子量 | 372.68 |
| 溶解度 | <9.32mg/ml in ethanol;<37.27mg/ml in DMSO |
| 储存条件 | Store at RT |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Sipatrigine, a neuroprotective agent, is a glutamate release inhibitor, voltage-dependent sodium channel and calcium channel inhibitor, penetrating the central nervous system. Has potential to treat focal cerebral ischemia and stroke[1][2]. References:
[1]. Leach MJ, et al. BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damage. Stroke. 1993 Jul;24(7):1063-7.
[2]. Atticus H. Hainsworth, et al. Sipatrigine (BW 619C89) is a Neuroprotective Agent and a Sodium Channel and Calcium Channel Inhibitor. CNS Drug Reviews. Vol. 6, No. 2, pp. 111-134. |
