RN 1747 是一种选择性瞬时受体电位阳离子通道亚家族 V 成员 4 (TRPV4) 激动剂，对 hTRPV4、mTRPV4 和 rTRPV4 的 EC50 值分别为 0.77 μM、4.0 μM 和 4.1 μM。
| Cas No. | 1024448-59-6 |
| 化学名 | 1-benzyl-4-((4-chloro-2-nitrophenyl)sulfonyl)piperazine |
| Canonical SMILES | ClC1=CC=C(C([N+]([O-])=O)=C1)S(=O)(N2CCN(CC3=CC=CC=C3)CC2)=O |
| 分子式 | C17H18ClN3O4S |
| 分子量 | 395.87 |
| 溶解度 | <39.59mg/ml in DMSO |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | RN-1747 is a selective transient receptor potential cation channel subfamily V member 4 (TRPV4) agonist, with EC50 values are 0.77 μM, 4.0 μM and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively. RN-1747 also antagonizes TRPM8, with an IC50 of 4 μM[1]. References:
[1]. Vincent F, et al. Identification and characterization of novel TRPV4 modulators. Biochem Biophys Res Commun. 2009 Nov 20;389(3):490-4. |
