7-Chlorokynurenic acid sodium salt

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CAS NO:

1263094-00-3

包装与价格：

包装	价格(元)
10mg	询价
50mg	询价

7-Chlorokynurenic acid sodium salt (7-CKA sodium salt) 是 N-甲基-D-天冬氨酸 (NMDA) 受体的甘氨酸 B 共激动剂位点的有效选择性拮抗剂 (IC50=0.56 μM)。

Cas No.	1263094-00-3
别名	7-氯犬尿喹啉酸钠盐,7-CKA sodium salt
化学名	sodium 7-chloro-4-oxo-1,4-dihydroquinoline-2-carboxylate
Canonical SMILES	ClC1=CC(N2)=C(C(C=C2C([O-])=O)=O)C=C1.[Na+]
分子式	C₁₀H₅ClNNaO₃
分子量	245.59
溶解度	Soluble to 100 mM in sterile water
储存条件	Desiccate at RT
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	7-Chlorokynurenic acid sodium salt is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid sodium salt is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid sodium salt has potent antinociceptive actions after neuraxial delivery[1][2]. Male Sprague-Dawley rats pretreated with 7-Chlorokynurenic acid sodium salt (10 nM) shows a significant retardation of development of both the electroencephalographic and motor (17.7±2.9 daily stimulations) components of the seizure response[3]. References: [1]. Kemp JA, et al. 7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex. Proc Natl Acad Sci U S A. 1988 Sep;85(17):6547-50. [2]. Yaksh TL, et al. Characterization of the Effects of L-4-Chlorokynurenine on Nociception in Rodents. J Pain. 2017 Oct;18(10):1184-1196. [3]. Croucher MJ, et al. 7-Chlorokynurenic acid, a strychnine-insensitive glycine receptor antagonist, inhibits limbic seizurekindling. Neurosci Lett. 1990 Oct 2;118(1):29-32.